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Portrait of Andy J. Chang, Ph.D.

Andy J. Chang, Ph.D.

Associate Director, Research Physiology

Andy employs multi-disciplinary approaches to develop in vivo models that enable our scientists to study the molecular mechanisms of signaling in aging.


Andy leads the Research Physiology team at Calico, working in close collaboration with our scientists to improve the study of aging through the expanded use of fit-for-purpose in vivo models. Through Calico’s external collaborations, Andy is also helping our scientists access new capabilities and expertise to accelerate in vivo projects.

Prior to Calico, Andy was an Assistant Professor of Physiology and an Investigator with the Cardiovascular Research Institute at the University of California, San Francisco. While at UCSF, he led an independent research lab focused on oxygen physiology and the development of a drug discovery program targeting Olfr78/OR51E2, a highly conserved GPCR of the olfactory receptor family that may be beneficial in the treatment of common diseases associated with aging.

  • Postdoc, Stanford University and Rockefeller University
  • Ph.D. in Cell Biology, University of California, San Francisco
  • A.B. in Biochemical Sciences, Harvard University