The following are selected peer-reviewed research papers published by Calico scientists.
A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence.
Lewis KN, Rubinstein ND, Buffenstein R.
Geroscience. 2018 Apr 20
The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.
Wong YL, LeBon L, Edalji R, Lim HB, Sun C, Sidrauski C.
elife. 2018 Feb 28
Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast
Gibney PA, Schieler A, Chen JC, Bacha-Hummel JM, Botstein M, Volpe M, Silverman SJ, Xu Y, Bennett BD, Rabinowitz JD, Botstein D.
Molecular Biolology of the Cell. 2018 Apr 15
Challenges in validating candidate therapeutic targets in cancer
Settleman J, Sawyers CL, Hunter T.
elife. 2018 Feb 8
Naked Mole-Rat mortality rates defy gompertzian laws by not increasing with age
Ruby JG, Smith M, Buffenstein R.
elife. 2018 Jan 24
A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage
Bohnert KA, Kenyon C.
Nature. 2017 Nov 30
Stem cells: Aging and transcriptional fingerprints
Keyes BE, Fuchs E.
Journal of Cell Biology. 2018 Jan 2
The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent
Grimes KM, Barefield DY, Kumar M, McNamara JW, Weintraub ST, de Tombe PP, Sadayappan S, Buffenstein R.
Pflugers Archive; European Journal of Physiology. 2017 Dec
A three-drug combination to treat BRAF-mutant cancers
Firestone AJ, Settleman J.
Nature Medicine. 2017 Aug 4
The protein kinase MBK-1 contributes to lifespan extension in daf-2 mutant and germline-deficient Caenorhabditis elegans
Mack HID, Zhang P, Fonslow BR, Yates JR.
Aging. 2017 May 25
How a Mutation that Slows Aging Can Also Disproportionately Extend End-of-Life Decrepitude
Podshivalova K, Kerr RA, Kenyon C.
Cell Reports. 2017 Apr 18
The Upsides and Downsides of Organelle Interconnectivity
Gottschling DE, Nyström T.
Cell. 2017 Mar 23
Extended Postnatal Brain Development in the Longest-Lived Rodent: Prolonged Maintenance of Neotenous Traits in the Naked Mole-Rat Brain
Orr ME, Garbarino VR, Salinas A, Buffenstein R.
Frontiers in Neuroscience. 2016 Nov 8
Cutting back on the essentials: Can manipulating intake of specific amino acids modulate health and lifespan?
Brown-Borg HM, Buffenstein R.
Ageing Research Reviews. 2017 Oct
Deep Proteome Analysis Identifies Age-Related Processes in C. elegans
Narayan V, Ly T, Pourkarimi E, Murillo AB, Gartner A, Lamond AI, Kenyon C.
Cell Systems. 2016 Aug
Unraveling the message: insights into comparative genomics of the naked mole-rat
Lewis KN, Soifer I, Melamud E, Roy M, McIsaac RS, Hibbs M, Buffenstein R.
Mammalian Genome. 2016 Aug
TORquing metabolic reprogramming in cancer cells
Pusapati R, Settleman J.
Cell Cycle. 2016 Sep 16
Reversible Age-Related Phenotypes Induced during Larval Quiescence in C. elegans
Roux AE, Langhans K, Huynh W, Kenyon C.
Cell Metabolism. 2016 Jun 14
Mechanisms regulating proteostasis are involved in sympatric speciation of the blind mole rat, Spalax galili
Rodriguez KA, Li K, Nevo E, Buffenstein R.
From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span.
McIsaac RS, Lewis KN, Gibney PA, Buffenstein R.
Annals of the New York Academy of Sciences. 2016 Jan
Communication in Drug Development: "Translating" Scientific Discovery
Settleman J, Cohen RL.
Cell. 2016 Mar 10
Cancer: Bet on drug resistance.
Nature. 2016 Jan 21
Sympatric speciation revealed by genome-wide divergence in the blind mole rat Spalax
Li K, Hong W, Jiao H, Wang GD, Rodriguez KA, Buffenstein R, Zhao Y, Nevo E, Zhao H.
Proceedings of the National Academy of Sciences. 2015 Sep 22
From cancer genomics to precision oncology--tissue's still an issue
Cohen RL, Settleman J.
Cell. 2014 Jun 19