The following are selected peer-reviewed research papers published by Calico scientists.
eIF2B activator prevents neurological defects caused by a chronic integrated stress response
Wong Y, LeBon L, Basso A, Kohlhaas K, Nikkel A, Robb H, Donnelly-Roberts D, Prakash J, Swensen A, Rubinstein N, Krishnan S, McAllister F, Haste N, O’Brien J, Roy M, Ireland A, Frost J, Shi L, Riedmaier S, Martin K, Dart M, Sidrauski C
eLife, 9 Jan 2019
A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast
Hendrickson D, Soifer I, Wranik B, Kim G, Robles M, Gibney P, McIsaac S.
eLife, 18 Oct 2018
Estimates of the heritability of human longevity are substantially inflated due to assortative mating.
Ruby G, Wright K, Rand K, Kermany A, Noto K, Curtis D, Varner N, Garrigan D, Slinkov D, Dorfman I, Granka J, Byrnes, J, Myres N, Ball C.
Genetics, 6 Nov 2018
A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence.
Lewis KN, Rubinstein ND, Buffenstein R.
Geroscience. 2018 Apr 20
The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.
Wong YL, LeBon L, Edalji R, Lim HB, Sun C, Sidrauski C.
elife. 2018 Feb 28
Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast
Gibney PA, Schieler A, Chen JC, Bacha-Hummel JM, Botstein M, Volpe M, Silverman SJ, Xu Y, Bennett BD, Rabinowitz JD, Botstein D.
Molecular Biolology of the Cell. 2018 Apr 15
Naked Mole-Rat mortality rates defy gompertzian laws by not increasing with age
Ruby JG, Smith M, Buffenstein R.
elife. 2018 Jan 24
A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage
Bohnert KA, Kenyon C.
Nature. 2017 Nov 30
The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent
Grimes KM, Barefield DY, Kumar M, McNamara JW, Weintraub ST, de Tombe PP, Sadayappan S, Buffenstein R.
Pflugers Archive; European Journal of Physiology. 2017 Dec
The protein kinase MBK-1 contributes to lifespan extension in daf-2 mutant and germline-deficient Caenorhabditis elegans
Mack HID, Zhang P, Fonslow BR, Yates JR.
Aging. 2017 May 25
How a Mutation that Slows Aging Can Also Disproportionately Extend End-of-Life Decrepitude
Podshivalova K, Kerr RA, Kenyon C.
Cell Reports. 2017 Apr 18
Extended Postnatal Brain Development in the Longest-Lived Rodent: Prolonged Maintenance of Neotenous Traits in the Naked Mole-Rat Brain
Orr ME, Garbarino VR, Salinas A, Buffenstein R.
Frontiers in Neuroscience. 2016 Nov 8
Deep Proteome Analysis Identifies Age-Related Processes in C. elegans
Narayan V, Ly T, Pourkarimi E, Murillo AB, Gartner A, Lamond AI, Kenyon C.
Cell Systems. 2016 Aug
Unraveling the message: insights into comparative genomics of the naked mole-rat
Lewis KN, Soifer I, Melamud E, Roy M, McIsaac RS, Hibbs M, Buffenstein R.
Mammalian Genome. 2016 Aug
Reversible Age-Related Phenotypes Induced during Larval Quiescence in C. elegans
Roux AE, Langhans K, Huynh W, Kenyon C.
Cell Metabolism. 2016 Jun 14
Mechanisms regulating proteostasis are involved in sympatric speciation of the blind mole rat, Spalax galili
Rodriguez KA, Li K, Nevo E, Buffenstein R.
From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span.
McIsaac RS, Lewis KN, Gibney PA, Buffenstein R.
Annals of the New York Academy of Sciences. 2016 Jan
Sympatric speciation revealed by genome-wide divergence in the blind mole rat Spalax
Li K, Hong W, Jiao H, Wang GD, Rodriguez KA, Buffenstein R, Zhao Y, Nevo E, Zhao H.
Proceedings of the National Academy of Sciences. 2015 Sep 22