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Portrait of Ari Firestone, Ph.D.

Ari Firestone, Ph.D.

Principal Investigator

Ari’s research focuses on identifying and validating novel therapeutic targets and strategies for the treatment of cancer.


A primary driver of the Firestone Lab’s work is the computational mining of large-scale functional genomics and phenotypic small-molecule screens to identify selective vulnerabilities in definable cancer subtypes.

Prior to joining Calico, Ari completed a postdoc in Kevin Shannon’s laboratory at the University of California at San Francisco working on novel strategies for targeting NRAS mutant hematological malignancies.

  • Postdoc, Laboratory of Kevin Shannon, University of California at San Francisco
  • Ph.D. in Chemical and Systems Biology, Stanford University
  • B.A. in Biology, Carleton College
  • Fellow of the Damon Runyon Cancer Research Foundation - 2012