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Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in KEAP1-Mutant Lung Cancer

Melat T Gebru, Timothy E Hoffman, Aaron Boudreau, Ngoc Vu, Fei Han, Putianqi Wang, Eddie Folk, Xiumin Wu, James Newton, Kelly D Foster-Duke, Jessica Gajda, Sammy Villa, Nianxin Yang, Celeste M Sandoval, Christian Grant, Samantha E Wildeboer, Wayne R Buck, Jonathan A Hickson, Ari J Firestone, Michael Kort, Bryson D Bennett, Brad Shotwell, Noel S Wilson, David Stokoe
Cancer Research September 18, 2025