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Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival

Yanan Chen, Rejani B Kunjamma, Karin Lin, Li Kai, Maria Dima, Kody Bruce, Ian Steckler, Young Hyun Che, Jason Chan-Zervas, Jaime Eugenin von Bernhardi, Caitlin Connelly, Sude Ece, Grace Newell, Dwight E Bergles, Carmela Sidrauski, Brian Popko
Nature Communications December 26, 2025