Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo

John T. Randolph, Matthew J. O’Connor, Fei Han, Charles W. Hutchins, Y. Amy Siu, Min Cho, Yunan Zheng, Jonathan A. Hickson, Jana L. Markley, Vlasios Manaves, Mikkel Algire, Kenton A. Baker, Alex M. Chapman, Sujatha M. Gopalakrishnan, Sanjay C. Panchal, Kelly Foster-Duke, DeAnne F. Stolarik, Anita Kempf-Grote, Darby Dammeier, Stacey Fossey, Qi Sun, Chaohong Sun, Yu Shen, Michael J. Dart, Warren M. Kati, Albert Lai, Ari J. Firestone and Michael E. Kort