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Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy

Irene Tom, Victoria C Pham, Kenneth J Katschke Jr, Wei Li, Wei-Ching Liang, Johnny Gutierrez, Andrew Ah Young, Isabel Figueroa, Shadi Toghi Eshghi, ChingWei V Lee, Jitendra Kanodia, Scott J Snipas, Guy S Salvesen, Phillip Lai, Lee Honigberg, Menno van Lookeren Campagne, Daniel Kirchhofer, Amos Baruch and Jennie R Lill
PNAS April 28, 2020