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May 9, 2024

Calico and Broad Institute Extend Collaboration Adding Focus on Age-Related Neurodegeneration

SOUTH SAN FRANCISCO, CA and CAMBRIDGE, MA, May 9, 2024 – Calico Life Sciences LLC (Calico) and the Broad Institute of MIT and Harvard, announced today that the two organizations have further extended their partnership with an added focus on age-related neurodegeneration. Initially announced in March 2015, this renewed agreement extends the collaboration until September 2029 and will continue to support ongoing programs focused on the biology and genetics of aging as well as early-stage drug discovery. Terms of the agreement were not disclosed.

We are pleased to continue our collaboration with the Broad Institute. It is entering its tenth year and we’ve made a considerable amount of progress, including discoveries that could make immunotherapies more effective for more patients. We are currently testing this approach in two early-stage clinical trials evaluating a pair of PTPN2 inhibitors,” said Arthur D. Levinson, Ph.D., Founder and CEO of Calico. “With the expansion of our partnership to include age-related neurodegeneration, we are tackling a critical area of discovery that will allow us to access our collective expertise to advance an important area of research and clinical development.”

“Renewing our commitment to this partnership with Calico reflects our shared goal of advancing transformative biomedical research and therapies for age-related diseases,” said Todd Golub, M.D., Director and founding core member of the Broad Institute. “Since we initiated our partnership, we have seen tremendous advances across new technologies and analytic methods that are enabling the discovery of new biological insights into human disease that have immediate impact on drug discovery. We look forward to working with the Calico team to further our insights into how aging impacts the brain and neurological function.”

About Calico

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. To learn more about Calico, visit

About Broad Institute of MIT and Harvard

Broad Institute of MIT and Harvard was launched in 2004 to empower this generation of creative scientists to transform medicine. The Broad Institute seeks to describe the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods and data openly to the entire scientific community.

Founded by MIT, Harvard, Harvard-affiliated hospitals, and the visionary Los Angeles philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff and students from throughout the MIT and Harvard biomedical research communities and beyond, with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide.

Image credit: Ben Gibbs for The Eli and Edythe Broad Foundation