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Portrait of J. Graham Ruby, Ph.D.

J. Graham Ruby, Ph.D.

Principal Investigator

Graham analyzes phenotypic and genetic data to study aging.


Graham’s lab is focused on the age-related decay of the extracellular matrix (ECM) and the adverse consequences of that decay on physiology. They employ a mixture of experimental approaches, across both wet and dry lab methods, that include genetic and image analysis of human cohort data, in vivo experiments supported by quantitative genetic and image/video analyses, and tissue-culture models of cellular behavior. 

As a postdoc with Dr. Joseph DeRisi at the University of California at San Francisco, Graham wrote software (PRICE) for the discovery of novel viruses from metagenomic deep-sequencing of clinical specimens. As a graduate student with Dr. David Bartel at MIT, he analyzed deep-sequence data for the annotation and characterization of microRNA genes.

  • Postdoc with Dr. Joseph DeRisi, University of California at San Francisco
  • Ph.D. in Biology, Massachusetts Institute of Technology
  • B.A. in Biology, Northwestern University