Scientist, Genomics

  • South San Francisco,
  • Full Time
  • R&D

Who we are:

Calico is a research and development company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan. We will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Executing on this mission will require an unprecedented level of interdisciplinary effort and a long-term focus for which funding is already in place.

Position description:

Calico is seeking an experienced scientist with a passion for Genomics research. You will join our Genomics Lab where your work takes advantage of a diverse array of next-gen sequencing and genome technology tools, including optical mapping and long read sequencing.  You are expected to participate in both wet-lab and computational efforts.  The results of your scientific efforts will directly contribute to Calico’s long-term mission to positively impact human healthspan and lifespan.


  • This is both a laboratory bench and computational position:
    • Design and conduct hands-on laboratory experiments
    • Develop new tools or use existing tools for data analysis
  • Provide expertise to other members of the Genomics Lab by collaborating with them to analyze experiments, e.g., transcript assembly, gene expression analysis, etc.
  • Improve Calico’s NGS lab methods, or innovate and create novel approaches
  • Devise experimental and computational solutions for mammalian genome analysis 
  • Present work at both internal meetings and external scientific conferences

Position requirements:

  • MS/PhD in molecular biology, genetics, genome sciences, bioengineering, bioinformatics, or related field
  • Hands-on NGS laboratory experience:
    • At least 3 years prior hand-on laboratory NGS experience e.g., Bionano Genomics, Pacific Biosciences, 10X Genomics, and Illumina
    • Demonstrated hands-on proficiency with extant NGS library technology e.g. RNA-seq, ChIP-seq, ATAC-seq, scRNA-seq, Iso-seq, etc.
  • NGS computational experience:
    • At least 3 years prior coding ability is required
    • Proficiency in Python and R as well as familiarity NGS bioinformatics analysis for gene expression analysis are required
    • Experience with genome assembly or analysis of structural variation is preferred



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