Calvin Jan, Ph.D.Calvin Jan, Ph.D. Principal Investigator

Research Focus

My lab utilizes sequencing technologies to address fundamental questions in cell biology. We are currently interested in the aging genome. Our research seeks to develop a quantitative framework for understanding how cells interpret and respond to genomic perturbations.

I have a long-standing interest in gene regulation fed largely by innovations in deep sequencing. As a Ph.D. student in David Bartel’s lab at the Whitehead, I studied the mechanisms and evolution of mRNA and small non-coding RNA biogenesis pathways. I then moved to the University of California, San Francisco, where as a postdoc with Jonathan Weissman, I developed methods based on ribosome profiling to interrogate translation with subcellular resolution.

Education

Honors & Awards