Eugene’s lab uses data from large human cohorts to study rates of physiological declines, the onset of chronic conditions, morbidity and mortality rates. Their main research focus is to develop a better understanding of key drivers of the aging process through the use of multiscale models. The theoretical work aims to capture molecular, physiological, and demographic outcome layers in a single epidemiological framework. The experimental work in the lab aims to identify longevity biomarkers and pathways critical to long term tissue homeostasis using large scale mass-spectrometry based profiling of human cohorts.

As a postdoc at Josh Rabinowitz group at Princeton University, Eugene developed bioinformatics tools to interpret metabolomics data from the isotopic flux and profiling studies. Prior to joining Calico, he served as a Senior Principal Scientist at Pfizer Oncology, working on the identification of novel oncology targets using integrative metabolomics/proteomics approaches. There, Eugene was responsible for the development of proteomics techniques to quantitate the absolute level of expression of cell surface receptors in human tissues.