Distinguished Principal Investigator
Dan’s research goal is to identify molecular changes that cause aging, as well as the downstream age-associated events that lead to cellular decline. His lab uses the budding yeast Saccharomyces cerevisiae as a model system for studying the aging process in eukaryotic cells. Over the past three decades, Dan has discovered and characterized new molecules and concepts in a number of areas of cell biology including telomeres and telomerase, DNA repair, epigenetics, protein quality control, mitochondria and lysosomes. His contributions from each of these areas have impacted research approaches in human biology.
Prior to joining Calico, he was a full member of the Fred Hutchinson Cancer Research Center from 1996 to 2015, as well as an affiliate professor in the department of Genome Sciences at the University of Washington School of Medicine from 2001 to 2015. Earlier in his career, Dan was an assistant and then associate professor at the University of Chicago. He received his Bachelor of Science degree in chemistry from Augustana College, his masters and doctorate degrees in chemistry from the University of Colorado and completed postdoctoral training at the Fred Hutchinson Cancer Research Center. Dan has received numerous awards and appointments, including election to the National Academy of Sciences and as a fellow of the American Academy of Arts and Sciences.