Head of Discovery Technologies
In addition to purification, Dan’s group also works on identifying and characterizing protein interactions, including aggregation using techniques such as SPR, ITC, TR-FRET and cell based binding assays.
Prior to Calico, Dan had an over 30 year career at Genentech. In the last 15 years there, he served as the Senior Director of the Protein Chemistry department overseeing Protein Purification, Protein Conjugation, Functional Genomics and Proteomics. Dan’s Genentech lab focused on protein purification/characterization, protein-protein interactions, and development of novel bispecific antibody platforms.
Unliganded Fibroblast Growth Factor Receptor 1 Forms Density-Independent Dimers
The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8+ T Cell Effector Function
Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell–cell adhesion and signaling mechanism that requires cis-trans receptor clustering