Head of Research
The Sidrauski lab studies stress signaling pathways and the numerous factors that maintain proteins in a functional state in the human cell, often referred to as the proteostasis network. They use a variety of techniques, ranging from biochemistry, cell biology, genetics and genome-scale molecular approaches to unravel the changes that take place in these networks in disease and with age.
In the Walter lab at the University of California, San Francisco, Carmela identified a potent small molecule that activates the translation initiation factor eIF2B and antagonizes the integrated stress response (ISR). Pharmacological modulation of this central pathway has many potential therapeutic avenues that Carmela’s lab is exploring. In her graduate work, Carmela studied the unfolded protein response and discovered that this interorganelle signaling pathway is mediated by an unconventional cytosolic splicing event catalyzed by a unique kinase/RNAse IRE1 and tRNA ligase.