My interests are in translational medicine and using an integrated physiological approach to understand metabolism in health, aging and disease. This includes the development and application of advanced biophysical techniques for in vivo analysis to provide an in-depth physiological understanding of fundamental scientific observation at the level of the whole organism.
Prior to joining Calico, I was at Genentech Inc., and gained more than 20 years of drug development experience. I was Director and Staff Scientist, and led new initiatives developing biomedical imaging for use in drug discovery and clinical development. I established a biomedical imaging department that pioneered the use of novel technologies, from magnetic resonance to positron emission and optical imaging. These technologies have provided unique insight into pharmacological treatment of disease.